Endothelial eNOS deficiency causes podocyte injury through NFAT2 and heparanase in diabetic mice
Abstract The pivotal role of endothelial nitric oxide synthase (eNOS) in diabetic nephropathy (DN) has been demonstrated using global eNOS knockout (eNOSGKO) mice.However, the precise role of endothelially expressed eNOS and how its deficiency advances DN are still unclear.Here, we targeted endothelial eNOS expression (E-eNOSKO) after the onset of